Avestin, Inc.

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Avestin headquarters building in Ottawa, Canada

Avestin | Precision High-Pressure Homogenizers & Liposome Extrusion Systems

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Applications

Polystyrene latex particle size distribution
An unprocessed dispersion with a starting size range of 10-100 microns (600X Magnification) & Processed sample of uniform, 1 micron particles (100X Magnification)

Dispersions

A whole range of dispersions can be run through EmulsiFlex high-pressure homogenizers to reduce particle size as well as make the size distribution uniform. EmulsiFlex homogenizers are involved in the processing of dispersions such as drug dispersions, herb extracts, industrial coatings, and pigments. Shown is a sample of a dry crystalline (amorphous) powder run through an EmulsiFlex homogenizer at 25000 psi/173 MPa.

Liposome size comparison after extrusion
Liposomes prepared using the EmulsiFlex high-pressure homogenizer, extruder, or both in combination. Combined homogenization yields 113.7 nm in one pass and 89.9 nm in two passes.

Liposomes

A control sample of unruptured Schizosaccharomyces pombe yeast. Schizosaccharomyces pombe after one pass at 28000 psi/193MPa through the EmulsiFlex-C160. Only cell fragments remain.

Emulsion before homogenization treatment
Emulsion after homogenization treatment results

Before: Pharmaceutical drug emulsion 'A' before processing. The starting particle size is large (5-10 microns) and the distribution wide.

After: Pharmaceutical emulsion 'A' after processing at 18000psi/124MPa. Note the dramatic reduction in size (52nm) and the narrower distribution.

Emulsions

Oil In Water Emulsion

Sample
Pressure (psi)
Diameter (nm)
Unprocessed
–
656
1 Pass
16,000
77
3 Passes
16,000
59
5 Passes
16,000
42

Pharmaceutical Emulsion

Sample
Homogenizing
Pressure (psi)
Mean Droplet
Diameter (nm)
Control
–
3,500
1 Pass
20,000
590
3 Passes
20,000
185
5 Passes
20,000
140
Cell rupture yeast cells before and after homogenization

Before: A control sample of unruptured Schizosaccharomyces pombe yeast.

After: Schizosaccharomyces pombe after one pass at 28000 psi/193MPa through the EmulsiFlex-C160. Only cell fragments remain.

Cell Rupture

Strain: Schizosaccharomyces pombe
Machine: EmulsiFlex-C160
Pressure: 28000 psi / 193 MPa

Sample
cfu/ml
% Viable
% NOT Viable
Control
5.1 × 107
~100
~0
1 Pass
5.0 × 103
0.01
99.99

Strain: E. coli (BL21)
Machine: EmulsiFlex-C160
Pressure: 20000 psi / 138 MPa

Sample
cfu/ml
% Viable
% NOT Viable
Control
4.06 × 109
~100
~0
1 Pass
1.77 × 107
0.44
99.56
2 Passes
1.70 × 106
0.04
99.96
3 Passes
2.4 × 104
5.9 × 10−4
~100

Trusted by Leading Institutions

Alkermes Pharmaceuticals logo Pfizer Pharmaceuticals Johnson & Johnson AstraZeneca Pharmaceuticals Baxter Healthcare Boehringer Ingelheim Gilead Pharmaceuticals GlaxoSmithKline GSK Memorial Sloan Kettering Merck Novartis Roche Pharmaceuticals Salk Institute Scripps Research Institute Bayer Pharmaceuticals Max Planck Institute Philipps University Marburg ETH Zurich University of Montpellier China National Petroleum Corporation JBF Industrial Korea Institute of Bioscience and Biotechnology

Contact Us

How did you hear about us?

WORLDWIDE

AVESTIN, Inc.
2450 Don Reid Dr.
Ottawa, ON, Canada
K1H 1E1
Tel: 1-888-AVESTIN (US & Canada)
or 1-613-736-0019
Fax: 1-613-736-8086
Email: avestin@avestin.com

EUROPE

Avestin Europe GmbH
Weinheimer Str. 64b,
68309
Mannheim, Germany
Tel: +49 621 724 5980
Fax: +49 621 724 5813
Email: avestin@avestin.net

About The Company

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